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Two-day hands-on DNA microarray technology workshop designed to introduce participants to the underlying technology and to provide laboratory experience with microarray production.
Registration required: https://secure.dbi.udel.edu/registration/microarray.cgi Deadline for registration is December 20th
7:30am – 9:00am, 102 Delaware Biotechnology Institute
Featured Speaker - Hui-Yin Harry Li, CEO, Wilmington PharmaTech
7:30 am Breakfast and Networking
8:00 am to 9:00 am Presentations
http://www.ocean.udel.edu/seminars/)
4:00 pm – 5:00pm, 202 Cannon Lab, Lewes via ITV 206 Robinson Hall, UD Campus
Dr. Linda Medlin, Alfred Wegener Institute - Bremerhaven, GERMANY
"Three European Union projects: ALGADEC, MICROPAD and FISH & CHIPS: Probes for algae on DNA chips"
Host: Kathy Coyne
Sponsored by the Program for Computational Systems Biology: A regional consortium advancing the field of Computational Biology; (www.dbi.tju.edu/CBAT for more details) and the Greater Philadelphia Bioinformatics Alliance (www.bioadvance.com).
“The Non-Coding Regions of the Human Genome Are Linked To Nearly All Known Genes through Short Conserved Blocks That Are Specific To Biological Processes”
Isidore Rigoutsos, Ph.D.
Manager, Bioinformatics and Pattern Discovery Group, Computational Biology Center, IBM Thomas J. Watson Research Center
Using an unsupervised pattern discovery approach, we processed the intergenic and intronic regions of all human chromosomes and exhaustively catalogued all variable-length, identically-conserved motifs that had multiplicities well above what would be expected by chance. Among the millions of discovered motifs, we found that a subset of more than 100,000 members – termed EWCSBs (for “exceptionally-well-conserved-short blocks”) – have additional instances in the untranslated and in the amino-acid coding regions of more than 90% of all known human genes. We found that these EWCSBs have several interesting properties. In particular, they arrange combinatorially in the untranslated or coding regions of many genes where they form mosaics. Also, their placement in the untranslated and coding regions of genes exhibits a strong bias with consecutive EWCSB instances being approximately 22 nucleotides apart. Additional analysis allows us to establish that EWCSBs are over-represented in a statistically-significant manner in genes participating in specific biological processes such as transcription, regulation of transcription, cell communication, signaling, transport, etc. Interestingly, for ~1/3 of the EWCSBs, we find that the intergenic and intronic instances of their reverse complement lie inside hundreds of thousands of non-overlapping regions that are predicted to fold into double-stranded, energetically-very-stable, hairpin-shaped RNA structures; moreover, in terms of sequence, the EWCSBs subsume many of the currently known microRNAs, thus suggesting a possible link to post-transcriptional gene silencing. Finally, preliminary analyses suggest that many of these human-genome-derived EWCSBs are also present in the genomes of other vertebrates and invertebrates where they associate with similar biological processes as in humans.
Time/Place: Thursday, January 19th, 3:00PM
(Tea served at 2:45 P.M.) Room 207, Jefferson Alumni Hall, 1020 Locust Street Philadelphia, PA
For directions and campus map please visit http://www.tju.edu/main/direct.cfm
If you would like to meet with the speaker please contact Dr. Greg Gonye at (215) 955-0580.
Support for this seminar series provided by the Daniel Baugh Institute for Functional Genomics/Computational Biology in the Department of Pathology, Anatomy and Cell Biology at TJU, the School of Engineering and the Delaware Biotechnology Institute at UD, a NIGMS National Program of Excellence in Biomedical Computing Grant, and the Greater Philadelphia Bioinformatics Alliance.
January 25, 2006
2:00pm, Conference Room 102
Delaware Biotechnology Institute
9:00am, 366 Colburn Lab
"Large-Scale Nonlinear Programming Approaches: Applications in Homeland Security"
Carl Lairdm, Chemical Engineering Department, Carnegie Melon University
Advisor: Professor Lorenz T. Biegler
Refreshments available at 8:45am
