Dr. Zhuang’s research group is investigating at a molecular level how eukaryotic cells cope with genotoxic stress through the DNA damage tolerance pathways. Several important proteins, including the specialized DNA polymerase eta, proliferating cell nuclear antigen (PCNA), and the deubiquitylating enzymes (DUB) are currently under investigation. The mechanism of enzyme action, as well as the regulation by reversible ubiquitylation and SUMOylation are being deciphered. In the mean time small-molecule inhibitors and peptidomimetic antagonists that modulate the essential factors and enzymes in DNA damage tolerance pathway are being discovered.
After earning his Ph.D. Dr. Zhuang served as a postdoctoral fellow at the Pennsylvania State University. He joined the faculty of University of Delaware in 2007.